Glial Cell Line-Derived Neurotrophic Factor Is Essential for Postnatal Survival of Midbrain Dopamine Neurons
نویسندگان
چکیده
منابع مشابه
Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.
Glial cell line-derived neurotrophic factor (GDNF) is one of the most potent trophic factors that have been identified for midbrain dopamine (DA) neurons. Null mutations for trophic factor genes have been used frequently for studies of the role of these important proteins in brain development. One problem with these studies has been that often only prenatal development can be studied because ma...
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...........................................................................................................................................ii Acknowledgements.........................................................................................................................iii Table of
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Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملGlial cell line-derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system.
BACKGROUND The enteric nervous system (ENS) continues its structural and functional growth after birth, with formation of ganglia and the innervation of growing smooth muscle. However, little is known about factors in the postnatal intestine that influence these processes. METHODS We examined the presence and potential role of glial cell line-derived nerve growth factor (GDNF) in the rat post...
متن کاملGlial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway.
It has been shown that the noradrenergic (NE) locus coeruleus (LC)-hippocampal pathway plays an important role in learning and memory processing, and that the development of this transmitter pathway is influenced by neurotrophic factors. Although some of these factors have been discovered, the regulatory mechanisms for this developmental event have not been fully elucidated. Glial cell line-der...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2000
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.20-09-03182.2000